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CAR-T细胞来源胞外体的治疗潜能——非细胞形态靶向治疗癌症

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发表于 2015-11-2 22:43:10 | 显示全部楼层 |阅读模式
CAR-T细胞来源胞外体的治疗潜能——非细胞形态靶向治疗癌症
嵌合抗原受体修饰的T细胞过继免疫治疗是一种治疗癌症的独特有前途的治疗方式。改造的嵌合抗原受体给T细胞提供了靶向抗肿瘤能力,并且通过刺激细胞增殖和增加细胞因子的产生来增强细胞抗癌活性。作为一种新型并且有潜能的治疗方式,它存在一些不可控制的过程,这些过程是产生不利事件的潜在因素。
作为这一有效形式的一种延伸,CAR-T细胞来源的胞外体可以替代CAR-T细胞作为最终的攻击者,从而克服一些局限性。胞外体保留亲本细胞大部分特点,通过传递它们到受体细胞,在细胞间的通信过程中扮演着重要作用。CAR-T细胞来源胞外体的应用将使这种细胞治疗临床可控,也为它提供了无细胞平台多样化的抗癌因子,从而有效应对癌症的复杂性和波动性。因此认为细胞和胞外体平台合理的应用将使这一有效的治疗方法更可行。
关键词:免疫治疗,嵌合抗原受体(CAR),exosomes,癌症治疗,CAR-T
Therapeutic potential of CAR-T cell-derived exosomes: a cell-free modality for targeted cancer therapy
Keywords: immunotherapy, chimeric antigen receptor (CAR), exosomes, cancer therapy, extracellular vesicles
Received: August 12, 2015  Accepted: October 06, 2015  Published: October 19, 2015
ABSTRACT
Chimeric antigen receptor (CAR)-based T-cell adoptive immunotherapy is a distinctively promising therapy for cancer. The engineering of CARs into T cells provides T cells with tumor-targeting capabilities and intensifies their cytotoxic activity through stimulated cell expansion and enhanced cytokine production.
As a novel and potent therapeutic modality, there exists some uncontrollable processes which are the potential sources of adverse events.As an extension of this impactful modality, CAR-T cell-derived exosomes may substitute CAR-T cells to act as ultimate attackers, thereby overcoming some limitations. Exosomes retain most characteristics of parent cells and play an essential role in intercellular communications via transmitting their cargo to recipient cells. The application of CAR-T cell-derived exosomes will make this cell-based therapy more clinically controllable as it also provides a cell-free platform to diversify anticancer mediators, which responds effectively to the complexity and volatility of cancer.
It is believed that the appropriate application of both cellular and exosomal platforms will make this effective treatment more practicable.

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