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间皮素靶向的嵌合抗原受体: 驱使T细胞对抗实体肿瘤

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发表于 2015-11-6 23:05:52 | 显示全部楼层 |阅读模式
间皮素靶向的嵌合抗原受体: 驱使T细胞对抗实体肿瘤
摘要:嵌合抗原受体(CAR)是种合成的抗体,它能靶向T细胞到癌症细胞表面的抗原,增强T细胞的功能和持久性。间皮素是一种与癌症侵袭相关的细胞表面抗原,在间皮瘤、肺癌、胰腺癌、乳腺癌、卵巢癌和其他癌细胞表面高度表达。间皮素在间皮中低表达,然而,干预治疗中需要考虑很多因素。值得鼓舞的是,最近的临床实验评价发现CAR在胰腺癌和间皮癌病人中显示了主动免疫或免疫偶联能力,并且没有毒性。总之,这些研究结果和临床前CAR治疗模型,不管在系统或者局部的T细胞传递中,证实了间皮素CAR-T细胞治疗方案在多种实体肿瘤中是有效的。
意义:随着最近靶向CD19 CAR-T细胞过继移植治疗难治性血液系统恶性肿瘤取得的成功,has generated much enthusiasm for T-cell engineering and raises the prospect of implementing similar strategies for solid tumors对T细胞的改造产生了很大的积极性,为使用类似的策略来对抗实体肿瘤带来了前景。
Mesothelin-Targeted CARs: Driving T Cells to Solid Tumors.
Abstract
Chimeric antigen receptors (CAR) are synthetic receptors that target T cells to cell-surface antigens and augment T-cell function and persistence. Mesothelin is a cell-surface antigen implicated in tumor invasion, which is highly expressed in mesothelioma and lung, pancreas, breast, ovarian, and other cancers. Its low-level expression in mesothelia, however, commands thoughtful therapeutic interventions. Encouragingly, recent clinical trials evaluating active immunization or immunoconjugates in patients with pancreatic adenocarcinoma or mesothelioma have shown responses without toxicity. Altogether, these findings and preclinical CAR therapy models using either systemic or regional T-cell delivery argue favorably for mesothelin CAR therapy in multiple solid tumors.
SIGNIFICANCE:
Recent success obtained with adoptive transfer of CAR T cells targeting CD19 in patients with refractory hematologic malignancies has generated much enthusiasm for T-cell engineering and raises the prospect of implementing similar strategies for solid tumors. Mesothelin is expressed in a wide range and a high percentage of solid tumors, which we review here in detail. Mesothelin CAR therapy has the potential to treat multiple solid malignancies.

 楼主| 发表于 2015-11-8 22:38:01 | 显示全部楼层
爱康得生物医学技术(苏州)有限公司,专注免疫治疗。
更多资讯,请关注http://www.icartab.com.cn/company_overview.html
发表于 2016-10-18 14:43:32 | 显示全部楼层
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