设为首页收藏本站
开启辅助访问
切换到窄版

 找回密码
 注册

QQ登录

只需一步,快速开始

搜索
查看: 1233|回复: 1

确定RNA结构的一种新方法(RNA in close-up)

[复制链接]
发表于 2013-2-24 12:42:46 | 显示全部楼层 |阅读模式
Genome-wide measurement of RNA secondary structure in yeast
尽管RNA结构对其调控和功能很重要,但在实验中已经了解的RNA结构相对很少,而且也
没有对RNA结构进行高通过量测量的实验方法。相反,计算方法是全基因组应用的标准
方法。不过,新技术已使人们能够在更大规模上对RNA结构进行计算。Kertesz等人利用
一种深度测序方法来确定酿酒酵母整个转录组的结构。他们获得的结果为二级结构在翻
译中的作用提供了有趣的提示,并且为研究这类结构何以能根据环境条件而改变搭建了
舞台。(Letter p. 103)
Genome-wide measurement of RNA secondary structure in yeast pp103-107
Experimental determination of the secondary structure of RNA molecules has
usually been carried out on a case-by-case basis. Now, however, a
deep-sequencing approach has been used to profile the secondary structure of
3,000 distinct messenger RNA transcripts from Saccharomyces cerevisiae. The
results provide interesting hints about the role of secondary structure in
protein translation, and set the stage for the examination of how such
structures can change in response to environmental conditions.
Michael Kertesz et al.
doi:10.1038/nature09322
Abstract:
http://www.nature.com/nature/journal/v467/n7311/abs/nature09322.html
Article:
http://www.nature.com/nature/journal/v467/n7311/full/nature09322.html
您需要登录后才可以回帖 登录 | 注册

本版积分规则

QQ|申请友链|小黑屋|手机版|Archiver|生物信息学论坛 ( 蜀ICP备09031721号  

GMT+8, 2017-2-22 07:42 , Processed in 0.096048 second(s), 19 queries .

Powered by Discuz! X3

© 2001-2013 Comsenz Inc.

快速回复 返回顶部 返回列表